Library Newsletter

The February 2015 edition of the library’s newsletter is now available!

Please follow this link to download our inaugural issue featuring:

  1. A tutorial on renewing library material online
  2. A list of new books in our scientific and recreational reading collections.
  3. Book recommendations from the library’s science informationist, John Borghi
  4. A description of select services offered by the library: Including Browzine, Mango Languages, and PubSubmit.
  5. A description of AHRQ’s new public access policy
  6. Answers to frequently asked questions: Including how to access library resources while off campus and accessing library materials available through the libraries at Weill Cornell and Memorial Sloan Kettering.

Thanks for reading!

Recommended Readings: Jef Boeke, Ph.D., March 13

Friday Lecture Series
Friday, March 13, 2015
3:45 p.m., Caspary Auditorium

Jef Boeke, Ph.D.
Professor,
Department of Biochemistry and Molecular Pharmacology,
Director, Institute for systems genetics,
New York University

Synthesis of Designer Chromosomes from Scratch

Recommended Readings

Empirical Articles

Annaluru, N., Muller, H., Mitchell, L. a, Ramalingam, S., Stracquadanio, G., Richardson, S. M., … Chandrasegaran, S. (2014). Total synthesis of a functional designer eukaryotic chromosome. Science, 344(6179), 55–58. doi:10.1126/science.1249252

Dymond, J. S., Richardson, S. M., Coombes, C. E., Babatz, T., Muller, H., Annaluru, N., … Boeke, J. D. (2011). Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature, 477(7365), 471–476. doi:10.1038/nature10403

Mitchell, L. a., & Boeke, J. D. (2014). Circular permutation of a synthetic eukaryotic chromosome with the telomerator. Proceedings of the National Academy of Sciences, 111(48), 17003–17010. doi:10.1073/pnas.1414399111

Reviews and Protocols

Cooper, E. M., Müller, H., Chandrasegaran, S., Bader, J. S., & Boeke, J. D. (2012). The build-a-genome course. Methods in Molecular Biology, 852, 273–283. doi:10.1007/978-1-61779-564-0_20

Recommended Readings: Tom Muir, Ph.D., March 27

Friday Lecture Series
Friday, March 27, 2015
3:45 p.m., Caspary Auditorium

Tom Muir, Ph.D.
Van Zandt Williams Jr. Class of ‘65 Professor of Chemistry,
Chair, Department of chemistry
Princeton University

‘Houdini’ Proteins: Discovery and Applications of Ultrafast Inteins

Recommended Readings

Empirical Articles

Shah, N. H., Dann, G. P., Vila-Perelló, M., Liu, Z., & Muir, T. W. (2012). Ultrafast protein splicing is common among cyanobacterial split inteins: Implications for protein engineering. Journal of the American Chemical Society, 134(28), 11338–11341. doi:10.1021/ja303226x

Shah, N. H., Eryilmaz, E., Cowburn, D., & Muir, T. W. (2013). Naturally split inteins assemble through a “capture and collapse” mechanism. Journal of the American Chemical Society, 135(49), 18673–18681. doi:10.1021/ja4104364

Shah, N. H., Vila-Perelló, M., & Muir, T. W. (2011). Kinetic control of one-pot trans-splicing reactions by using a wild-type and designed split intein. Angewandte Chemie, 50(290, 6511–6515. doi:10.1002/anie.201102909

Vila-Perelló, M., Liu, Z., Shah, N. H., Willis, J. A., Idoyaga, J., & Muir, T. W. (2013). Streamlined expressed protein ligation using split inteins. Journal of the American Chemical Society, 135(1), 286–292. doi:10.1021/ja309126m

Review Papers

Eryilma, E., Shah, N. H., Muir, T. W., & Cowburn, D. (2014). Structural and dynamical features of Inteins and implications on protein splicing. Journal of Biological Chemistry, 289(21), 14506–14511. doi:10.1074/jbc.R113.540302

Shah, N. H., & Muir, T. W. (2014). Inteins: Nature’s Gift to Protein Chemists. Chemical Science, 5(1), 446–461. doi:10.1016/j.biotechadv.2011.08.021.Secreted

Recommended Readings: Gabriel Victora, Ph.D., March 9

Special Lecture
Monday, March 9, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gabriel Victora, Ph.D.
Principal Investigator,
Whitehead Fellow,
Whitehead Institute for Biomedical Research

Darwin in Miniature: Antibody Evolution in Germinal Centers

Recommended Readings

Empirical Articles

Schwickert, T. a, Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., … Nussenzweig, M. C. (2011). A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. The Journal of Experimental Medicine, 208(6), 1243–1252. doi:10.1084/jem.20102477

Shulman, Z., Gitlin, A. D., Targ, S., Jankovic, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013). T follicular helper cell dynamics in germinal centers. Science, 341(6146), 673–677. doi:10.1126/science.1241680

Victora, G. D., Dominguez-sola, D., Holmes, A. B., Deroubaix, S., Dalla-favera, R., & Nussenzweig, M. C. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood, 120(11), 2240–2248. doi:10.1182/blood-2012-03-415380.

Victora, G. D., Schwickert, T. a., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010). Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell, 143(4), 592–605. doi:10.1016/j.cell.2010.10.032

Review Papers

Victora, G. D., & Mesin, L. (2014). Clonal and cellular dynamics in germinal centers. Current Opinion in Immunology, 28, 90-96. doi:10.1016/j.coi.2014.02.010

Victora, G. D., & Nussenzweig, M. C. (2012). Germinal Centers. Annual Review of Immunology, 30, 429-457. doi:10.1146/annurev-immunol-020711-075032

Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D., March 6

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, March 6, 2015
3:45 p.m., Caspary Auditorium

Jean-Laurent Casanova, M.D., Ph.D.,
Senior Attending Physician, Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Infectious Diseases of Childhood: Inborn Errors of Immunity?

Recommended Readings

Empirical Articles

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., … Casanova, J.-L. (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314(5797), 308–312. doi:10.1126/science.1128346

Taramasso, L., Boisson-Dupuis, S., Garre, M. L., Bondi, E., Cama, a, Nozza, P., … Marazzi, M. G. (2014). Pineal germinoma in a child with interferon-gamma receptor 1 deficiency. case report and literature review. Journal of Clinical Immunology, 34(8), 922–927. doi:10.1007/s10875-014-0098-0

Von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., … Casanova, J.-L. (2008). Pyogenic bacterial infections in humans with MyD88 deficiency. Science, 321(5889), 691–696. doi:10.1126/science.1158298

Review Papers

Casanova, J.-L., & Abel, L. (2002). Genetic dissection of immunity to mycobacteria: the human model. Annual Review of Immunology, 20, 581–620. doi:10.1146/annurev.immunol.20.081501.125851

Casanova, J.-L., & Abel, L. (2013). The genetic theory of infectious diseases: a brief history and selected illustrations. Annual Review of Genomics and Human Genetics, 14, 215–243. doi:10.1146/annurev-genom-091212-153448

Conley, M. E., & Casanova, J. L. (2014). Discovery of single-gene inborn errors of immunity by next generation sequencing. Current Opinion in Immunology, 30, 17–23. doi:10.1016/j.coi.2014.05.004

Recommended Readings: Natasha Mhatre, Ph.D., March 4

Special Seminar
Wednesday, March 4, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Natasha Mhatre, Ph.D.
Postdoctoral Research Fellow,
University of Toronto at Scarborough

The Sensory Ecology and Evolutionary Origins of Actively Amplified Mechanotransduction:
From Insects to Algae

Recommended Readings

Empirical Articles

Mhatre, N., Montealegre-Z, F., Balakrishnan, R., & Robert, D. (2012). Changing resonator geometry to boost sound power decouples size and song frequency in a small insect. Proceedings of the National Academy of Sciences, 109(22), E1444–E1452. doi:10.1073/pnas.1200192109

Mhatre, N., & Robert, D. (2013). A tympanal insect ear exploits a critical oscillator for active amplification and tuning. Current Biology, 23(19), 1952–1957. doi:10.1016/j.cub.2013.08.028

Rajaraman, K., Mhatre, N., Jain, M., Postles, M., Balakrishnan, R., & Robert, D. (2013). Low pass filters and differential tympanal tuning in a paleotropical bushcricket with an unusually low frequency call. Journal of Experimental Biology, 216(5), 777–787. doi:10.1242/jeb.078352

Review Paper

Mhatre, N. (2015). Active amplification in insect ears: mechanics, models and molecules. Journal of Comparative Physiology A, 201(1), 19–37. doi:10.1007/s00359-014-0969-0

Recommended Readings: Jue Chen, Ph.D., February 27

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, February 25, 2015
3:45 p.m., Caspary Auditorium

Jue Chen, Ph.D.,
Head of Laboratory of Membrane Biology and Biophysics,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Understanding Molecular Pumps: Insights from Structural BiologyRecommended Readings

Empirical Articles

Chen, S., Oldham, M. L., Davidson, A. L., & Chen, J. (2013). Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. Nature, 499(7458), 364-368. doi:10.1038/nature12232

Jin, M. S., Oldham, M. L., Zhang, Q., & Chen, J. (2012). Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature. 490(7421), 566-569. doi:10.1038/nature11448

Oldham, M. L., Chen, S., & Chen, J. (2013). Structural basis for substrate specificity in the Escherichia coli maltose transport system. Proceedings of the National Academy of Sciences, 110(45), 18132-18137. doi:10.1073/pnas.1311407110

Review Papers

Chen, J. (2013). Molecular mechanism of the Escherichia coli maltose transporterCurrent Opinion in Structural Biology, 23(4), 492-498. doi: 10.1016/j.sbi.2013.03.011

Recommended Readings: Lingyin Li, Ph.D., February 25

Special Lecture
Wednesday, February 25, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Lingyin Li, Ph.D.,
Merck Fellow of the Jane Coffins Child Memorial Fund,
Department of Systems Biology,
Harvard Medical School

Chemical Biology of Anti-Cancer Innate Immunity

Recommended Readings

Kim, S., Li, L., Maliga, Z., Yin, Q., Wu, H., & Mitchison, T. J. (2013). Anticancer flavonoids are mouse-selective STING agonists. ACS Chemical Biology, 8(7), 1396–1401. doi:10.1021/cb400264n

Li, L., Yin, Q., Kuss, P., Maliga, Z., Wu, H., & Mitchison, T. J. (2014). Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology, 10(12), 1043–1048. doi:10.1038/nchembio.1661

Recommended Readings: Eva Nogales, Ph.D., February 20

Friday Lecture Series
Friday, February 20, 2015
3:45 p.m., Caspary Auditorium

Eva Nogales, Ph.D.
Professor of Biochemistry, Biophysics and Structural Biology,
University of California, Berkeley
Senior Faculty Scientist, Life Sciences Division,
Lawrence Berkeley National Laboratory
Investigator, Howard Hughes Medical Institute

Cryo-EM Studies of the Human Transcription Initiation Machinery

Recommended Readings

Cianfrocco, M. a, & Nogales, E. (2013). Regulatory interplay between TFIID’s conformational transitions and its modular interaction with core promoter DNA. Transcription, 4(3), 1–7. doi:10.4161/trns.25291

Cianfrocco, M. A., Kassavetis, G. A., Grob, P., Fang, J., Juven-Gershon, T., Kadonaga, J. T., & Nogales, E. (2013). Human TFIID binds to core promoter DNA in a reorganized structural state. Cell, 152(1-2), 120–131. doi:10.1016/j.cell.2012.12.005

He, Y., Fang, J., Taatjes, D. J., & Nogales, E. (2013). Structural visualization of key steps in human transcription initiation. Nature, 495(7442), 481–486. doi:10.1038/nature11991

Recommended Readings: Robert McGinty, M.D., Ph.D., February 18th

Special Lecture,
Wednesday, February 18th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Robert McGinty, M.D., Ph.D.
Damon Runyun Postdoctoral Fellow,
Dale F. Frey Breakthrough Scientist,
Department of Biochemistry & Molecular Biology,
The Pennsylvania State University

Chemistry, Crystallography and Nucleosome Ubiquitylation

Recommended Readings

Empirical Articles

Kim, J., Kim, J., McGinty, R. K., Nguyen, U. T., Muir, T. W., Allis, C. D., & Roeder, R. G. (2013). The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell, 49(6), 1121-1133. doi:10.1016/j.molcel.2013.01.034

McGinty, R. K., Henrici, R. C., & Tan, S. (2014). Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514(7524), 591-596. doi:10.1038/nature13890

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T., Kim, J., Sun, X. J., … & Roeder, R. G. (2013). SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2), 297-310. doi:10.1016/j.cell.2013.06.027

Review Papers

McGinty, R. K., & Tan, S. (In Press). Nucleosome structure and function. Chemical Reviews. doi:10.1021/cr500373h