Recommended Readings: Robert Lefkowitz, M.D. May 9

Friday Lecture Series
Friday, May 9, 2014
3:45 p.m., Carson Family Auditorium

Robert Lefkowitz, M.D.
James B. Duke Professor of Medicine
Professor of Biochemistry
Duke University
Investigator, Howard Hughes Medical Institute

Seven Transmembrane Receptors

Recommended Readings:

Empirical Articles

Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., … Lefkowitz, R. J. (2011). A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature, 477(7364), 349–353. doi:10.1038/nature10368

Kahsai, A. W., Xiao, K., Rajagopal, S., Ahn, S., Shukla, A. K., Sun, J., … Lefkowitz, R. J. (2011). Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology, 7(10), 692–700. doi:10.1038/nchembio.634

Rajagopal, S., Ahn, S., Rominger, D. H., Gowen-macdonald, W., Lam, C. M., Dewire, S. M., … Lefkowitz, R. J. (2011). Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology, 80(3), 367–3. doi:10.1124/mol.111.072801.

Shukla, A. K., Manglik, A., Kruse, A. C., Xiao, K., Reis, R. I., Tseng, W.-C., … Lefkowitz, R. J. (2013). Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature, 497(7447), 137–141. doi:10.1038/nature12120

Review Papers

DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007). β-Arrestins and Cell Signaling. Annual Review of Physiology, 69(1), 483–510. doi:10.1146/annurev.physiol.69.022405.154749

Lefkowitz, R. J., & Shenoy, S. K. (2005). Transduction of receptor signals by beta-arrestins. Science, 308(5721), 512–517. doi:10.1126/science.1109237

Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002). Seven-transmembrane receptors. Nature Reviews Molecular Cell Biology, 3(9), 639–50. doi:10.1038/nrm908

Wisler, J. W., Xiao, K., Thomsen, A. R., & Lefkowitz, R. J. (2014). Recent developments in biased agonism. Current Opinion in Cell Biology, 27, 18–24. doi:10.1016/j.ceb.2013.10.008

Recommended Readings: David Kingsley, Ph.D.

Friday Lecture Series

The Fairfield Osborn Memorial Lecture

Fishing for the Secrets of Vertebrate Evolution

David Kingsley, Ph.D., professor, developmental biology, Stanford University;

investigator, Howard Hughes Medical Institute

April 18, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

han, Y. F., Marks, M. E., Jones, F. C., Villarreal Jr., G., Shapiro, M. D., Brady, S. D., . . . Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer. Science, 327(5963), 302-305

Haussler, D., O’Brien, S. J., Ryder, O. A., Keith Barker, F., Clamp, M., Crawford, A. J., . . . Turner, S. (2009). Genome 10K: A proposal to obtain whole-genome sequence for 10000 vertebrate species. Journal of Heredity, 100(6), 659-674

Jones, F. C., Grabherr, M. G., Chan, Y. F., Russell, P., Mauceli, E., Johnson, J., . . . Kingsley, D. M. (2012). The genomic basis of adaptive evolution in threespine sticklebacks. Nature, 484(7392), 55-61

Kingsley, D. M., Zhu, B., Osoegawa, K., De Jong, P. J., Schein, J., Marra, M., . . . Myers, R. (2004). New genomic tools for molecular studies of evolutionary change in threespine sticklebacks. Behaviour, 141(11-12), 1331-1344

Lowe, C. B., Kellis, M., Siepel, A., Raney, B. J., Clamp, M., Salama, S. R., . . . Haussler, D. (2011). Three periods of regulatory innovation during vertebrate evolution. Science, 333(6045), 1019-1024

Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006). Parallel genetic origins of pelvic reduction in vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 103(37), 13753-13758

 

Recommended Readings: Hermann Steller, Ph.D May 5

Monday Lecture Series
Monday, May 5, 2014
4:00 p.m., Carson Family Auditorium

Hermann Steller, Ph.D
Strang Professor, Strang Laboratory of Apoptosis and Cancer Biology
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Regulation of Protein Degradation in Development, Aging and Disease

Recommended Readings:

Empirical Articles

Bader, M., Benjamin, S., Wapinski, O. L., Smith, D. M., Goldberg, A. L., & Steller, H. (2011). A conserved F box regulatory complex controls proteasome activity in Drosophila. Cell, 145(3), 371–382. doi:10.1016/j.cell.2011.03.021

Cho-Park, P. F., & Steller, H. (2013). Proteasome regulation by ADP-ribosylation. Cell, 153(3), 614–627. doi:10.1016/j.cell.2013.03.040

Review Papers

Finley, D. (2009). Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annual Review of Biochemistry, 78(1), 477–513. doi:10.1146/annurev.biochem.78.081507.101607

Glickman, M. H., & Ciechanover, A. (2002). The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiological Reviews, 82(2), 373–428. doi:10.1152/physrev.00027.2001

Murata, S., Yashiroda, H., & Tanaka, K. (2009). Molecular mechanisms of proteasome assembly. Nature Reviews Molecular Cell Biology, 10(2), 104–15. doi:10.1038/nrm2630

Recommended Readings: Mark M. Davis, Ph.D. April 25

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Mark M. Davis, Ph.D.
Burt and Marion Avery Family Professor of Immunology
Director, Stanford Institute for Immunity, Transplantation and Infection
Member, Bio-X and Stanford Cancer Institute
Stanford University

Reinventing Human Immunology

Recommended Readings:

Davis, M. M. (2008). A prescription for human immunology. Immunity, 29(6), 835–838. doi:10.1016/j.immuni.2008.12.003

Davis, M. M. (2012). Immunology taught by humans. Science Translational Medicine, 4(117), 117fs2. doi:10.1126/scitranslmed.3003385

Kidd, B. a, Peters, L. a, Schadt, E. E., & Dudley, J. T. (2014). Unifying immunology with informatics and multiscale biology. Nature Immunology, 15(2), 118–127. doi:10.1038/ni.2787

Maecker, H. T., McCoy, J. P., & Nussenblatt, R. (2012). Standardizing immunophenotyping for the Human Immunology Project. Nature Reviews Immunology, 12(3), 191–200. doi:10.1038/nri3158

Su, L. F., Han, A., McGuire, H. M., Furman, D., Newell, E. W., & Davis, M. M. (2014). The Promised Land of Human Immunology. Cold Spring Harbor Symposia on Quantitative Biology. doi:10.1101/sqb.2013.78.022905

Recommended Readings: Susan L. Ackerman, Ph.D. May 2

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Susan L. Ackerman, Ph.D.
Professor, The Jackson Laboratory
Investigator, Howard Hughes Medical Institute

Multicopy Genes Encoding Functional RNAs and Their Role in the CNS

Recommended Readings:

Empirical Articles

Jia, Y., Mu, J. C., & Ackerman, S. L. (2012). Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell, 148(1-2), 296–308. doi:10.1016/j.cell.2011.11.057

Liu, Y., Zaun, H. C., Orlowski, J., & Ackerman, S. L. (2013). CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. The Journal of Neuroscience, 33(31), 12656–12669. doi:10.1523/JNEUROSCI.0406-13.2013

Zhao, L., Longo-Guess, C., Harris, B. S., Lee, J.-W., & Ackerman, S. L. (2005). Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nature Genetics, 37(9), 974–979. doi:10.1038/ng1620

Review Papers

Cooper, T. A, Wan, L., & Dreyfuss, G. (2009). RNA and disease. Cell, 136(4), 777–793. doi:10.1016/j.cell.2009.02.011

Lemmens, R., Moore, M. J., Al-Chalabi, A., Brown, R. H., & Robberecht, W. (2010). RNA metabolism and the pathogenesis of motor neuron diseases. Trends in Neurosciences, 33(5), 249–258. doi:10.1016/j.tins.2010.02.003

Recommended Readings: Wiley Prize in Biomedical Sciences

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Deborah E. Wiley, chair, The Wiley Foundation, Welcome

Gunter Blobel, Ph.D., chair, Wiley Prize Jury, Award Presentation and Introduction of Award Lecture

William G. Kaelin, Jr., M.D., professor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School; investigator, Howard Hughes Medical Institute, Lessons from von Hippel-Lindau Disease

Steven McKnight, Ph.D., professor and chairman, department of biochemistry, University of Texas Southwestern Medical Center, Hitting the Bullseye of HIF2a, the Kidney Cancer Oncoprotein

Peter J. Ratcliffe, M.D., professor and head, Nuffield Department of Medicine, University of Oxford, From Epo to Oxygen: Elucidation of Hypoxia Sensing in Animals

Gregg L. Semenza, M.D., Ph.D., professor and director, vascular program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Regulation of Oxygen Homeostasis by Hypoxia-inducible Factors

April 11, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beckmann, R., Spahn, C. M. T., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., . . . Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell, 107(3), 361-372

Kaelin Jr., W. G., & McKnight, S. L. (2013). Influence of metabolism on epigenetics and disease. Cell, 153(1), 56-69

McKnight, S. L. (2010). On getting there from here. Science, 330(6009), 1338-1339

Ratcliffe, P. J. (2013). Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer. Journal of Physiology, 591(8), 2027-2042

Semenza, G. L. (2013). Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene, 32(35), 4057-4063

 

 

Recommended Readings: David D. Ho, M.D. April 21

Monday Lecture Series
Monday, April 21, 2014
4:00 p.m., Carson Family Auditorium

David D. Ho, M.D.
Irene Diamond Professor
Senior Physician
Scientific Director
Chief Executive Officer
Aaron Diamond AIDS Research Center
The Rockefeller University

Long-acting Antibodies and Drugs as Prophylactics in HIV Prevention

Recommended Readings:

Empirical Papers

Andrews, C. D., Spreen, W. R., Mohri, H., Moss, L., Ford, S., Gettie, A., … Ho, D. D. (2014). Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus. Science, 343(6175), 1151–1154. doi:10.1126/science.1248707

Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., … Celum, C. (2012). Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. The New England Journal of Medicine, 367(5), 399–410. doi:10.1056/NEJMoa1108524

Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., … Glidden, D. V. (2010). Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. The New England Journal of Medicine, 363(27), 2587–2599. doi:10.1056/NEJMoa1011205

Song, R., Oren, D. a, Franco, D., Seaman, M. S., & Ho, D. D. (2013). Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity. Nature Biotechnology, 31(11), 1047–1052. doi:10.1038/nbt.2677

Review Articles

Spreen, W. R., Margolis, D. a, & Pottage, J. C. (2013). Long-acting injectable antiretrovirals for HIV treatment and prevention. Current Opinion in HIV and AIDS, 8(6), 565–571. doi:10.1097/COH.0000000000000002

Recommended Readings: David Ginty, Ph.D.

Friday Lecture Series

The Sensory Neurons of Touch

David Ginty, Ph.D., Edward R. and Anne G. Lefler Professor,

department of neurobiology, Harvard Medical School;

investigator, Howard Hughes Medical Institute

April 4, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abraira, V., & Ginty, D. (2013). The sensory neurons of touch. Neuron, 79(4), 618-639

Deppmann, C. D., Mihalas, S., Sharma, N., Lonze, B. E., Niebur, E., & Ginty, D. D. (2008). A model for neuronal competition during development. Science, 320(5874), 369-373

Li, L., Rutlin, M., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., . . . Ginty, D. D. (2011). The functional organization of cutaneous low-threshold mechanosensory neurons. Cell, 147(7), 1615-1627

Luo, W., Wickramasinghe, S. R., Savitt, J. M., Griffin, J. W., Dawson, T. M., & Ginty, D. D. (2007). A hierarchical NGF signaling cascade controls ret-dependent and ret-independent events during development of nonpeptidergic DRG neurons. Neuron, 54(5), 739-754

Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., . . . Ginty, D. D. (2006). A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Molecular Cell, 21(2), 283-294

Wickramasinghe, S. R., Alvania, R. S., Ramanan, N., Wood, J. N., Mandai, K., & Ginty, D. D. (2008). Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron, 58(4), 532-545

 

Recommended Readings: James E. Darnell, Jr., M.D. May 19

Monday Lecture Series
Monday, May 19, 2014
4:00 p.m., Carson Family Auditorium

James E. Darnell, Jr., M.D.
Vincent Astor Professor Emeritus
The Rockefeller University

Then and now – making mRNA: an unbiased (?) look at pre-mRNA synthesis and processing

Recommended Readings:

Empirical Papers

Brenner, S., Jacob, F., & Meselson, M. (1961). An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature, 180(4776), 576–581.

Gros, F., Hiatt, H., Gilbert, W., & Kurland, C. (1961). Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli. Nature, 190(4776), 581–585.

Jacob, F., & Monod, J. (1961). Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology, 3, 318–356.

Scherrer, K., Latham, H., & Darnell, J. E. (1963). Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proceedings of the National Academy of Sciences, 49(2), 240–248.

Review Articles

Darnell, J. E. (1968). Ribonucleic acids from animal cells. Bacteriological Reviews, 32(3), 262–290.

Darnell, J. E. (2013). Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture. RNA, 19(4), 443–60. doi:10.1261/rna.038596.113

Licatalosi, D. D., & Darnell, R. B. (2010). RNA processing and its regulation: global insights into biological networks. Nature Reviews Genetics, 11(1), 75–87. doi:10.1038/nrg2673

Recommended Readings: David Kingsley, Ph.D. April 18

Friday Lecture Series
Friday, April 18, 2014
3:45 p.m., Caspary Auditorium

David Kingsley, Ph.D.
HHMI and Department of Developmental Biology
Stanford University School of Medicine

Fishing for the secrets of vertebrate evolution

Recommended Readings:

Empirical Papers

Chan, Y. F., Marks, M. E., Jones, F. C., Villarreal, G., Shapiro, M. D., Brady, S. D., … Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science, 327(5963), 302–305. doi:10.1126/science.1182213

Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., … Kingsley, D. M. (2005). Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles. Science, 307(5717), 1928–1933. doi:10.1126/science.1107239

Jones, F. C., Grabherr, M. G., Chan, Y. F., Russell, P., Mauceli, E., Johnson, J., … Kingsley, D. M. (2012). The genomic basis of adaptive evolution in threespine sticklebacks. Nature, 484(7392), 55–61. doi:10.1038/nature10944

Miller, C. T., Beleza, S., Pollen, A. a, Schluter, D., Kittles, R. a, Shriver, M. D., & Kingsley, D. M. (2007). cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans. Cell, 131(6), 1179–1189. doi:10.1016/j.cell.2007.10.055

Shapiro, M. D., Marks, M. E., Peichel, C. L., Blackman, B. K., Nereng, K. S., Jónsson, B., … Kingsley, D. M. (2004). Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature, 428(6984), 717–723. doi:10.1038/nature02415

Review Articles

McKinnon, J. S., & Rundle, H. D. (2002). Speciation in nature: the threespine stickleback model systems. Trends in Ecology & Evolution, 17(10), 480–488. doi:10.1016/S0169-5347(02)02579-X